Publications - Kloosterman Research Group

Deceuninck, L.; Kloosterman, F.

Awake hippocampal replay is not required for short-term memory Unpublished

bioRxiv 2022.11.03.514989, 2022.

den Bakker, H.; Dijck, M. Van; Sun, J-J.; Kloosterman, F.

Sharp-wave ripple associated activity in the medial prefrontal cortex supports spatial rule switching Unpublished

bioRxiv 2022.11.03.515023, 2022.

Michon, F.; Krul, E.; Sun, J-J.; Kloosterman, F.

Single-trial dynamics of hippocampal spatial representations are modulated by reward value Journal Article

In: Current Biology, vol. 31, no. 20, pp. 4423–4435, 2021.

Michon, F.; Sun, J-J.; Kim, C. Y.; Ciliberti, D.; Kloosterman, F.

Post-learning Hippocampal Replay Selectively Reinforces Spatial Memory for Highly Rewarded Locations Journal Article

In: Current Biology, vol. 29, no. 9, pp. 1436–1444, 2019.

Tanila, H.; Ku, S.; Kloosterman, F.; Wilson, M. A.

Characteristics of CA1 place fields in a complex maze with multiple choice points Journal Article

In: Hippocampus, vol. 28, no. 2, pp. 81–96, 2018, ISSN: 1098-1063.

@article{pmid29072798,

title = {Characteristics of CA1 place fields in a complex maze with multiple choice points},

author = {H. Tanila and S. Ku and F. Kloosterman and M. A. Wilson},

doi = {10.1002/hipo.22810},

issn = {1098-1063},

year  = {2018},

date = {2018-02-01},

urldate = {2018-02-01},

journal = {Hippocampus},

volume = {28},

number = {2},

pages = {81--96},

abstract = {For the sake of rigorous control of task variables, hippocampal place cells have been usually studied in relatively simple environments. To approach the situation of real-life navigation in an urban-like environment, we recorded CA1 place cells while rats performance a memory task in a "Townmaze" with two start locations, three alternate paths in the maze midsection, followed by a two-way choice that determined the trial outcome, access to a goal compartment. Further, to test the ability of place cells to update their spatial representation upon local changes in the environment while maintaining the integrity of the overall spatial map to allow effective navigation, we occasionally introduced barriers in the maze mid-section to force the rat to select a nonpreferred route. The "Townmaze" revealed many new interesting features of CA1 neurons. First, we found neurons with 3-5 fields that appear to represent segments on a single common route through the maze. Second, we found neurons with 3-5 fields similarly aligned along the longitudinal or transverse maze axis. Responses to the barriers were assessed separately near and far from the barriers. Appearance of new fields in response to the barriers took place almost exclusively only locally near the barrier, whereas in-field firing rate changes occurred throughout the maze. Further, field location changes did not correlate with the task performance, whereas firing rate changes did. These findings suggest that in a complex environment with blocked distal views, CA1 neurons code for the environment as sequences of significant nodes but are also capable of extracting and associating common elements across these sequences.},

keywords = {hippocampus, spatial code},

pubstate = {published},

tppubtype = {article}

}

Close

Gomperts, S. N.; Kloosterman, F.; Wilson, M. A.

VTA neurons coordinate with the hippocampal reactivation of spatial experience Journal Article

In: Elife, vol. 4, pp. e05360, 2015.

Kloosterman, F.; Layton, S. P.; Chen, Z.; Wilson, M. A.

Bayesian decoding using unsorted spikes in the rat hippocampus Journal Article

In: Journal of Neurophysiology, vol. 111, no. 1, pp. 217–227, 2014.

Chen, Z.; Kloosterman, F.; Brown, E. N.; Wilson, M. A.

Uncovering spatial topology represented by rat hippocampal population neuronal codes Journal Article

In: Journal of Computational Neuroscience, vol. 33, no. 2, pp. 227–255, 2012.

Nguyen, D. P.; Kloosterman, F.; Barbieri, R.; Brown, E. N.; Wilson, M. A.

Characterizing the dynamic frequency structure of fast oscillations in the rodent hippocampus Journal Article

In: Frontiers in Integrative Neuroscience, vol. 3, pp. 11, 2009.

Davidson, T. J.; Kloosterman, F.; Wilson, M. A.

Hippocampal replay of extended experience Journal Article

In: Neuron, vol. 63, no. 4, pp. 497–507, 2009.

Poon, N.; Kloosterman, F.; Wu, C.; Leung, L. S.

Presynaptic GABA(B) receptors on glutamatergic terminals of CA1 pyramidal cells decrease in efficacy after partial hippocampal kindling Journal Article

In: Synapse, vol. 59, no. 3, pp. 125–134, 2006.

Kloosterman, F.; Haeften, T.; da Silva, F. H. Lopes

Two reentrant pathways in the hippocampal-entorhinal system Journal Article

In: Hippocampus, vol. 14, no. 8, pp. 1026–1039, 2004.

Kloosterman, F.; Haeften, T. Van; Witter, M. P.; Silva, F. H. Lopes Da

Electrophysiological characterization of interlaminar entorhinal connections: an essential link for re-entrance in the hippocampal-entorhinal system Journal Article

In: European Journal of Neuroscience, vol. 18, no. 11, pp. 3037–3052, 2003.

Kloosterman, F.; Peloquin, P.; Leung, L. S.

Apical and basal orthodromic population spikes in hippocampal CA1 in vivo show different origins and patterns of propagation Journal Article

In: Journal of Neurophysiology, vol. 86, no. 5, pp. 2435–2444, 2001, ISSN: 0022-3077.

@article{pmid11698533,

title = {Apical and basal orthodromic population spikes in hippocampal CA1 in vivo show different origins and patterns of propagation},

author = {F. Kloosterman and P. Peloquin and L. S. Leung},

doi = {10.1152/jn.2001.86.5.2435},

issn = {0022-3077},

year  = {2001},

date = {2001-11-01},

urldate = {2001-11-01},

journal = {Journal of Neurophysiology},

volume = {86},

number = {5},

pages = {2435--2444},

abstract = {There is controversy concerning whether orthodromic action potentials originate from the apical or basal dendrites of CA1 pyramidal cells in vivo. The participation of the dendrites in the initialization and propagation of population spikes in CA1 of urethan-anesthetized rats in vivo was studied using simultaneously recorded field potentials and current source density (CSD) analysis. CSD analysis revealed that the antidromic population spike, evoked by stimulation of the alveus, invaded in succession, the axon initial segment (stratum oriens), cell body and approximately 200 microm of the proximal apical dendrites. Excitation of the basal dendrites of CA1, following stimulation of CA3 stratum oriens, evoked an orthodromic spike that started near the cell body or initial segment and then propagated approximately 200 microm into the proximal apical dendrites. In contrast, the population spike that followed excitation of the apical dendrites of CA1 initiated at the proximal apical dendrites, 50-100 microm distal to the cell body layer, and then propagated centripetally to the cell body and the proximal basal dendrites. A late apical dendritic spike may arise in the mid-apical dendrites (250-300 microm from the cell layer) and propagated distally. The origin or the pattern of propagation of each population spike type was similar for near-threshold to supramaximal stimulus intensities. In summary, population spikes following apical dendritic and basal dendritic excitation in vivo appeared to originate from different locations. Apical dendritic excitation evoked a population spike that initiated in the proximal apical dendrites while basal dendritic excitation evoked a spike that started near the initial segment or cell body. An original finding of this study is the propagation of the population spike from basal to apical dendrites in vivo or vice versa. This backpropagation from one dendritic tree to the other may play an important role in the synaptic plasticity among a network of CA3 to CA1 neurons.},

keywords = {hippocampus},

pubstate = {published},

tppubtype = {article}

}

Close

There is controversy concerning whether orthodromic action potentials originate from the apical or basal dendrites of CA1 pyramidal cells in vivo. The participation of the dendrites in the initialization and propagation of population spikes in CA1 of urethan-anesthetized rats in vivo was studied using simultaneously recorded field potentials and current source density (CSD) analysis. CSD analysis revealed that the antidromic population spike, evoked by stimulation of the alveus, invaded in succession, the axon initial segment (stratum oriens), cell body and approximately 200 microm of the proximal apical dendrites. Excitation of the basal dendrites of CA1, following stimulation of CA3 stratum oriens, evoked an orthodromic spike that started near the cell body or initial segment and then propagated approximately 200 microm into the proximal apical dendrites. In contrast, the population spike that followed excitation of the apical dendrites of CA1 initiated at the proximal apical dendrites, 50-100 microm distal to the cell body layer, and then propagated centripetally to the cell body and the proximal basal dendrites. A late apical dendritic spike may arise in the mid-apical dendrites (250-300 microm from the cell layer) and propagated distally. The origin or the pattern of propagation of each population spike type was similar for near-threshold to supramaximal stimulus intensities. In summary, population spikes following apical dendritic and basal dendritic excitation in vivo appeared to originate from different locations. Apical dendritic excitation evoked a population spike that initiated in the proximal apical dendrites while basal dendritic excitation evoked a spike that started near the initial segment or cell body. An original finding of this study is the propagation of the population spike from basal to apical dendrites in vivo or vice versa. This backpropagation from one dendritic tree to the other may play an important role in the synaptic plasticity among a network of CA3 to CA1 neurons.

Close